Problematic placebos in physical therapy trials
نویسندگان
چکیده
منابع مشابه
The Use of Placebos in Acupuncture Trials
The standard way to establish the scientific credentials of a medical treatment is to show that it is more effective than a placebo. With pharmaceuticals, it is relatively easy to make a suitable placebo, but with acupuncture things are not so straightforward. A variety of placebos have been used in acupuncture trials. This paper examines the implications of the choice of placebo for (1) proper...
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Placebos remain highly controversial therapies largely because of their widespread use in research as a comparator rather than a focus of analysis. While a recent systematic review of placebo versus no therapy arms in trials found no difference, the placebo effect in some areas of drug trial research is large and increasing. We attempt to explain this paradox and suggest how clinicians may use ...
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Recent debates over the use of sham surgery as a control for studies of fetal tissue transplantation for Parkinson's disease have focused primarily on rival interpretations of the US federal regulations governing human-subjects research. Using the core ethical and methodological considerations that underwrite the equipoise requirement, we find strong prima facie reasons against using sham surge...
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Changes in substance use should lead to subsequent improvements in health, but this topic is infrequently studied empirically. In this study, health effects were analyzed for a total of 835 Internet help-seekers who participated in one of two randomized controlled trials (RCTs) to reduce either alcohol or drug use following online assessment and brief intervention. Health effects over 12 months...
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BACKGROUND Unblinding effects may introduce bias into clinical trials. The use of active placebos to mimic side-effects of medication may therefore produce more rigorous evidence on the efficacy of antidepressants. METHOD Trials comparing antidepressants with active placebos were located. A standard measure of effect was calculated for each trial and weighted pooled estimates obtained. Hetero...
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ژورنال
عنوان ژورنال: Journal of Evaluation in Clinical Practice
سال: 2016
ISSN: 1356-1294
DOI: 10.1111/jep.12582